The smart Trick of ceesdekker That No One is Discussing

The smart Trick of ceesdekker That No One is Discussing

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Making use of single-molecule optical and AFM imaging and drive-spectroscopy tactics, we seek out to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our exploration passions contain:

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Around the similar time, the group of Paul McEuen, who was then based for the University of California, Berkeley, confirmed related outcomes on ropes of bundled nanotubes. Based on the wrapping angle, nanotubes can are available metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard College independently verified working with scanning tunnelling spectroscopy experiments.

Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on one molecules and steel clusters

We acquire position-of-care diagnostics exam of neglected tropical health conditions within just resource-limited configurations, determined by Crspr/Cas9 detecting of pathogen’s DNA in entire body fluids.

Illustration (3) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in grey, the rim with the pore is highlighted in crimson, along with a 3D rendering of your motion of the DNA rod is shown.

We form microorganisms into types that deviate from their all-natural phenotype. Specially, I'll present our ability to condition Stay E. coli microorganisms into novel designs like rectangles, squares, triangles and circles.

2000, discovery that nanotubes can have remarkable substantial current densities; settled the controversial difficulty of electronic transport by DNA molecules by measurements ceesdekker of insulating behavior at the single molecule degree; and demonstration of the AFM technique for single-molecule manipulation of nanotubes

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Resolving the step dimension in condensin-driven DNA loop extrusion identifies ATP binding because the stage-producing procedure

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Cees Dekker is Distinguished University Professor at TU Delft. Educated like a physicist, he pioneered nanotechnology with several discoveries on carbon nanotubes from the nineteen nineties. Due to the fact 2000, he moved to one-molecule biophysics and nanobiology. His latest exploration concentrates on (i) nanopores for protein sequencing; (ii) chromosome framework, particularly SMC motor protein; and (iii) building a living artificial mobile from lifeless molecules. Dekker is undoubtedly an elected member on the KNAW and fellow on the APS along with the IOP.

Developments in nanotechnology within the 1990s produced creating electronic gadgets from single molecules a chance. Cees Dekker recounts how his group developed a space-temperature transistor depending on just one carbon nanotube.

Supercoiling-dependent DNA binding: quantitative modeling and apps to bulk and single-molecule experiments